Affiliation:
1. Biogipuzkoa Health Research Institute Tissue Engineering Group Donostia‐San Sebastián Spain
2. Department of Biomedical Engineering and Sciences Tecnun‐University of Navarra Donostia‐San Sebastián Spain
Abstract
AbstractSkin forms the outer barrier of the body. Upon injury, successful wound healing in normal skin restores tissue damage and counteracts the loss of extracellular matrix (ECM) proteins and cells. Collagens and elastin are the most abundant structural proteins of the ECM. In homeostasis, collagen type I is the prevalent form, but it is replaced by type III collagen upon wounding, and only later remodelled. In turn, unsuccessful healing results in scars, which tend to be inflexible and inelastic as compared to normal elastic dermis. Scar inelasticity may be due to the absence of mature elastin fibre formation and cross‐linking. In this review, the available information on the process of formation of new collagen and elastic fibres during wound healing is analysed. The distinct roles of elastin and collagen proteins during healing are revisited and future research directions proposed which may help improve clinical management of open wounds and scars.
Funder
Instituto de Salud Carlos III
Eusko Jaurlaritza
Cited by
4 articles.
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