Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme inTrypanosoma brucei

Author:

Valente Maria1,Timm Jennifer2,Castillo-Acosta Víctor M.1,Ruiz-Pérez Luis M.1,Balzarini Tom1,Nettleship Joanne E.3,Bird Louise E.3,Rada Heather3,Wilson Keith S.2,González-Pacanowska Dolores1

Affiliation:

1. Instituto de Parasitología y Biomedicina “López-Neyra”, Consejo Superior de Investigaciones Científicas; Granada Spain

2. York Structural Biology Laboratory, Department of Chemistry; University of York; York YO10 5DD UK

3. The Oxford Protein Production Facility, Research Complex at Harwell, Rutherford Appleton Laboratory; R92 Harwell Didcot Oxfordshire OX11 0FA UK

Funder

Junta de Andalucía

Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile

Institute of Infection and Immunity

Plan Nacional

Federación Española de Enfermedades Raras

PARAMET

TRYPOBASE

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Reference70 articles.

1. Thymine metabolism and thymineless death in prokaryotes and eukaryotes;Ahmad;Annu Rev Microbiol,1998

2. The role of thymidine kinases in the activation of pyrimidine nucleoside analogues;Al-Madhoun;Mini Rev Med Chem,2004

3. Expression of thymidine kinase is essential to low dose radiation resistance of rat glioma cells;Al-Nabulsi;Cancer Res,1994

4. Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines;Ali;Mol Pharmacol,2013

5. GTP is the primary activator of the anti-HIV restriction factor SAMHD1;Amie;J Biol Chem,2013

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