Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents
Author:
Affiliation:
1. Department of Neurotoxicology; Mossakowski Medical Research Centre; Pol Acad Sci; Warsaw; Poland
2. Institute of Biotechnology; Warsaw University of Technology; Warsaw; Poland
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1471-4159.2012.07917.x/fullpdf
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3. Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone;Biswas;Oncogene,1999
4. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines;Bobola;Clin. Cancer Res.,2005
5. p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor;Bocangel;Anticancer Res.,2009
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