Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion-Reference-Cited by-同舟云学术

Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion

Published:2008-04 Issue:1 Volume:105 Page:165-176
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J Neurochem

Author:

Martínez-Azorín Francisco,Calleja Manuel,Hernández-Sierra Rosana,Farr Carol L.,Kaguni Laurie S.,Garesse Rafael

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1471-4159.2007.05122.x/fullpdf

Reference63 articles.

1. Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

2. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

3. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced.

4. Mutation analysis in 16 patients with mtDNA depletion

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