Affiliation:
1. Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Jinan China
2. National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital/Institute of Mental Health, The Key Laboratory of Mental Health, Ministry of Health Peking University Beijing China
Abstract
AbstractObjectiveTo estimate whether genetically proxied periodontitis causally impacts the brain cortical structure using Mendelian randomization (MR).BackgroundPeriodontitis is one of the most prevalent inflammatory conditions globally, and emerging evidence has indicated its influences on distal organs, including the brain, whose disorders are always accompanied by magnetic resonance imaging (MRI)‐identified brain cortical changes. However, to date, no available evidence has revealed the association between periodontitis and brain cortical structures.MethodsThe instrumental variables (IVs) were adopted from previous genome‐wide association study (GWAS) studies and meta‐analyses of GWAS studies of periodontitis from 1844 to 5266 cases and 8255 to 12 515 controls. IVs were linked to GWAS summary data of 51 665 patients from the ENIGMA Consortium, assessing the impacts of genetically proxied periodontitis on the surficial area (SA) or the cortical thickness (TH) of the global and 34 MRI‐identified functional regions of the brain. Inverse‐variance weighted was used as the primary estimate; the MR pleiotropy residual sum and outlier (MR‐PRESSO), the MR–Egger intercept test, and leave‐one‐out analyses were used to examine the potential horizontal pleiotropy.ResultsGenetically proxied periodontitis affects the SA of the medial orbitofrontal cortex, the lateral orbitofrontal cortex, the inferior temporal cortex, the entorhinal cortex, and the temporal pole, as well as the TH of the entorhinal. No pleiotropy was detected.ConclusionsPeriodontitis causally influences the brain cortical structures, implying the existence of a periodontal tissue–brain axis.
Reference38 articles.
1. Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action
2. Risk factor collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017;GBD 2017;Lancet,2018
3. Neuroinflammation: A Distal Consequence of Periodontitis
4. Oral frailty and neurodegeneration in Alzheimer’s disease
5. Chronic oral infection: An emerging risk factor of cerebral small vessel disease