A porcine model of complement activation-related pseudoallergy to nano-pharmaceuticals: Pros and cons of translation to a preclinical safety test-Reference-Cited by-同舟云学术

A porcine model of complement activation-related pseudoallergy to nano-pharmaceuticals: Pros and cons of translation to a preclinical safety test

Published:2018-04-27 Issue:1 Volume:1 Page:63-73
ISSN:2639-9431
Container-title:Precision Nanomedicine
language:en
Short-container-title:PRNANO

Author:

Szebeni János¹^ORCID,Bedőcs Péter²^ORCID,Dézsi László¹,Urbanics Rudolf³^ORCID

Affiliation:

1. Nanomedicine Research and Education Center, Semmelweis University, Budapest, Hungary

2. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

3. SeroScience Ltd., Budapest, Hungary

Abstract

Pigs provide a sensitive and quantitative animal model of non-IgE-mediated(pseudoallergic) hypersensitivity reactions (HSRs) caused by liposomes and many other nanoparticulate drugs or drug-carrier nanosystems (nanomedicines). The rapidly arising symptoms, including cardiopulmonary, hemodynamic, hematological, blood chemistry and skin changes, resemble the clinical picture in man undergoing infusion reactions toreactogenic nanoparticles. In addition to summarizing the basic features of the pig CARPA model, thereviewconsiderssome of the advantages and disadvantages of using the modelforpreclinical evaluation of nanomedicine safety.

Funder

Seventh Framework Programme

Publisher

Andover House Inc

Subject

General Medicine

Link

https://precisionnanomedicine.com/api/v1/articles/6475-a-porcine-model-of-complement-activation-related-pseudoallergy-to-nano-pharmaceuticals-pros-and-cons-of-translation-to-a-preclinical-safety-test.pdf

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