Innovative prospects for the creation of biologically active complexes based on a polysaccharide matrix

Author:

Shelepov V. G.1,Byambaa Badarch2,Chelnakova N. G.3,Pozniakovsky V. M.4

Affiliation:

1. Siberian Federal Research Center for Agrobiotechnology RAS

2. Mongolian Academy of Agrarian Sciences

3. Artlife

4. Kemerovo State Medical University,

Abstract

The possibility of combining complexly soluble arabinogalactan polysaccharides with chitosan polysaccharides to increase the absorption of biologically active substances and compounds characterized by low bioavailability is being considered. Included in the biologically active biopolymer matrix are chitosan succinate, succinic anhydrite, arabinogalactan and dihydroquercetin, respectively, in quantities, wt. %: 3–5.0; 2.0–4.0; 15.0–20.0 and 3.5 can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, including enzymes, nucleic acids, vitamins, hormones, etc. to certain cells, in particular, hepatocytes (liver parenchyma cells). The high membranotropic properties of arabinogalactan isolated from larch have been established, which allows its use to increase the absorption in the gastrointestinal tract of other functionally active ingredients with low bioavailability. The mechanism of this action is associated with the formation of a binding complex between arabinogalactan and the delivered agent, which has the ability to interact with the asialoglycoprotein cell receptor. Studies have been carried out on the possibility of combining arabinogalactan polysaccharides with chitosan polysaccharides to obtain a biopolymer matrix, which includes chitosan succinate, succinic anhydride and arabinogalactan containing dihydroquercetin not covalently bound to it. Along with the above properties, the effectiveness of using arabinogalactan is shown using the example of its use to improve the technological and functional characteristics of broiler chicken meat with PSE traits. The addition of arabinogalactan to the recipe composition of minced meat during the production of sausages, in an amount of 0.5% of the main raw material, increased the moisture-binding capacity by 5% while reducing losses during heat treatment by 6%. There was an improvement in peroxide and acid numbers during storage, which ensures inhibition of oxidative processes and prevents spoilage of finished products.

Publisher

FSBEI HE Voronezh State University of Engineering Technologies

Reference20 articles.

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2. Arifkhodzhaev A.O. Galactans and galactan-containing polysaccharides of higher plants. Chemistry of natural compounds. 2000. no. 3. pp. 185–197. (in Russian).

3. Babkin V.A., Ostroukhova L.A., Malkov Yu.A., Ivanova S.Z. et al. Biologically active substances from larch wood. Chemistry for sustainable development. 2001. vol. 9. no. 3. pp. 363–367. (in Russian).

4. Grishin A.A. Chitin and chitosan: Chemistry, biological activity, application. News of universities. Applied chemistry and biotechnology. 2014. vol. 6. no. 1. pp. 29–34. (in Russian).

5. Ovodov Yu.S. Polysaccharides of flowering plants: structure and physiological activity. Bioorganic chemistry. 1998. vol. 24. no. 7. pp. 483–501. (in Russian).

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