Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS-Reference-Cited by-同舟云学术

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Simultaneous determination of clopidogrel, 2-oxo-clopidogrel, and the thiol metabolite of clopidogrel in human plasma by LC-MS/MS

Published:2022 Issue:2 Volume:36 Page:109
ISSN:1674-8301
Container-title:The Journal of Biomedical Research
language:
Short-container-title:J Biomed Res

Author:

Xu Lei,Li Ran,Li Juan,Dong Zhou,Zong Jiaxin,Tan Chuchu,Ye Zekang,Shi Lu,Gong Xiaoxuan,Li Chunjian

Publisher

Journal of Biomedical Research

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.jbr-pub.org.cn/fileSWYXYJZZYWB/journal/article/swyxyjzzywb/2022/2/JBR-2021-0125.pdf

Reference26 articles.

1. Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y₁₂ adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis[J]. Semin Thromb Hemost, 2005, 31(2): 174–183.

2. Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity[J]. Circulation, 2003, 107(23): 2908–2913.

3. Heestermans AACM, van Werkum JW, Schömig E, et al. Clopidogrel resistance caused by a failure to metabolize clopidogrel into its metabolites[J]. J Thromb Haemost, 2006, 4(5): 1143–1145.

4. Tang M, Mukundan M, Yang J, et al. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol[J]. J Pharmacol Exp Ther, 2006, 319(3): 1467–1476.

5. Kubica A, Kozinski M, Grzesk G, et al. Genetic determinants of platelet response to clopidogrel[J]. J Thromb Thrombolysis, 2011, 32(4): 459–466.

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