Estimation of hydromechanical parameters of limb lymphedematous tissue with the use of chamber tests

Abstract

Purpose: In this paper, in vivo methods of estimation of the shear modulus and hydraulic permeability of subcutaneous tissue of lower limb are presented. Methods: The experimental technique is based on single- or two-chamber inflation-deflation tests in which temporal changes in limb circumference under the test chamber for cyclic loading are registered. Simplified models for fast undrained deformation and slow creep of oedematous tissue with squeezing out interstitial liquid were considered. Finite element simulations of the chamber test within a finite deformation poroelastic model were elaborated. Results: Formulas necessary to estimate the shear modulus and permeability of subcutaneous tissue were derived and then tested or calibrated using the results of poroelastic simulations. An example of application of the derived formulas for clinical data obtained from the chamber test was discussed. Conclusions: A simple in vivo methods of estimation of the hydromechanical properties of lymphedematous tissue (shear modulus and permeability) were proposed. The strengths and weaknesses of the proposed methodology were discussed.