Aerobic exercise improves postprandial inflammatory and hemostatic markers after a high-fat meal: a randomized crossover study

Author:

Teixeira Bruno Costa12,Krüger Renata Lopes13,Farinha Juliano Boufleur1,Boeno Franccesco Pinto12,Macedo Rodrigo Cauduro Oliveira14,Fonseca Gabriel Alves1,Bandinelli Eliane5,Duarte Marta Maria Medeiros Frescura6,Reischak-Oliveira Alvaro1

Affiliation:

1. Program of Human Movement Sciences, School of Physical Education, Physiotherapy and Dance (ESEFID), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS 90690-200, Brazil.

2. Physical Education School, Regional Integrated University of Alto Uruguay and the Missions (URI), São Luiz Gonzaga, RS 97800-000, Brazil.

3. Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

4. University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, RS 96815-900, Brazil.

5. Institute of Bioscience – Genetics Department, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS 91501-970, Brazil.

6. Program of Pharmacology, Health Sciences Center (CCS), Federal University of Santa Maria (UFSM), Santa Maria, RS 97105-900, Brazil.

Abstract

Exercise intensity modulates postprandial lipemia. However, its effect on hemostatic and pro- and anti-inflammatory markers in the postprandial state is still unknown. Eleven young males performed a 2-day trial on different conditions: (i) REST: rest for 45 min; (ii) MIE: moderate-intensity exercise; and (iii) HIE: heavy-intensity exercise. Experimental conditions were performed in the evening. On the following morning, blood samples were taken in the fasted state (0 h) and at 1, 3, and 5 h after the consumption of a high-fat meal (HFM). Interleukin-10 (IL-10) levels were higher in the HIE vs. MIE trial at 0 and 1 h (p < 0.033) and IL-10 incremental area under the curve (iAUC) was greater in the MIE (p = 0.027) and HIE (p = 0.045) trials vs. REST. Lower levels of anti-coagulation factor VII (FVII) were observed at 1 h in the MIE condition vs. REST (p = 0.043). In comparison with REST, MIE improved hemostatic (FVII) and anti-inflammatory markers (IL-10 iAUC) whereas HIE enhanced IL-10 in the postprandial state. Regardless of the exercise intensity, aerobic exercise mitigates the deleterious consequences of an HFM. Novelty: Prior aerobic exercise at moderate-intensity attenuates next day’s postprandial FVII and IL-10 levels whereas exercise performed at heavy-intensity increases IL-10 levels. Moderate-intensity exercise may be more beneficial to improve hemostatic (FVII) and anti-inflammatory (IL-10) responses while heavy-intensity exercise may improve anti-inflammatory (IL-10) levels only.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

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