Nutrition and immunity: perspectives on key issues and next steps

Author:

Dunbar Carolyn L.1,Aukema Harold M.2,Calder Philip C.34,Gibson Deanna L.5,Henrickson Sarah E.67,Khan Saad89,Mailhot Geneviève1011,Panahi Shirin1213,Tabung Fred K.14,Tom Mei15,Upton Julia E.M.1617,Winer Daniel A.89181920,Field Catherine J.1

Affiliation:

1. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada

2. Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada

3. School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK

4. NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK

5. Department of Biology, Faculty of Science, Okanagan Campus, The University of British Columbia, Kelowna, BC, Canada

6. Division of Allergy Immunology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

7. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

8. Division of Cellular and Molecular Biology, Diabetes Research Group, Toronto General Research Institute (TGHRI), University Health Network, Toronto, ON, Canada

9. Department of Immunology, University of Toronto, Toronto, ON, Canada

10. CHU Sainte-Justine Research Center, Montreal, QC, Canada

11. Department of Nutrition, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada

12. Department of Physical Education, Université Laval, Quebec City, QC, Canada

13. Canadian Nutrition Society, Ottawa, ON, Canada

14. Department of Internal Medicine, Division of Medical Oncology, College of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

15. Nutrition Service, Alberta Health Services, Edmonton, AB, Canada

16. Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

17. Division of Immunology and Allergy, Department of Pediatrics, SickKids Food Allergy and Anaphylaxis Program, Hospital for Sick Children, Toronto, ON, Canada

18. Buck Institute for Research on Aging, Novato, CA, USA

19. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA

20. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Abstract

In January 2022, a group of experts came together to discuss current perspectives and future directions in nutritional immunology as part of a symposium organized by the Canadian Nutrition Society. Objectives included (1) creating an understanding of the complex interplay between diet and the immune system from infants through to older adults, (2) illustrating the role of micronutrients that are vital to the immune system, (3) learning about current research comparing the impact of various dietary patterns and novel approaches to reduce inflammation, autoimmune conditions, allergies, and infections, and (4) discussing select dietary recommendations aimed at improving disease-specific immune function. The aims of this review are to summarize the symposium and to identify key areas of research that require additional exploration to better understand the dynamic relationship between nutrition and immune function.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

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