OBSERVATIONS ON SOME EFFECTS OF THE SODIUM SALTS OF CERTAIN MONOCARBOXYLIC ACIDS ON ESTABLISHED CELL LINES

Author:

Pace Donald M.,Aftonomos Byron Th.,Elliott Alice,Sommer Steven

Abstract

There appears to be very little information in the literature pertaining to concentrations of various air pollutants or tobacco-smoke constituents that may be toxic or nontoxic to tissue cells cultivated in vitro. We have undertaken the task of ascertaining these levels and this report records observations concerning the first few of many known pollutants.The effects of the sodium salts of 10 monocarboxylic acids (formate, acetate, propionate, butyrate, valerate, caproate, oenanthylate, caprylate, caprate, and benzoate) on several established cell lines (HeLa, strain L, human lung, human skin) were studied.All of these compounds at a concentration of 10 mg% were toxic to the cell lines tested with the exceptions of formate, acetate, and benzoate on strain L, and of valerate and caprylate on human lung.All the compounds either stimulated proliferation or had no significant effect at 1 mg% except caproate and benzoate, which were toxic to human lung and human skin cells, respectively.

Publisher

Canadian Science Publishing

Subject

General Medicine

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3