Overexpression of a metacaspase gene stimulates cell growth and stress response inSchizosaccharomyces pombe-Reference-Cited by-同舟云学术

Overexpression of a metacaspase gene stimulates cell growth and stress response inSchizosaccharomyces pombe

Published:2007-08 Issue:8 Volume:53 Page:1016-1023
ISSN:0008-4166
Container-title:Canadian Journal of Microbiology
language:en
Short-container-title:Can. J. Microbiol.

Author:

Lim Hye-Won¹²,Kim Su-Jung¹²,Park Eun-Hee¹²,Lim Chang-Jin¹²

Affiliation:

1. Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University, College of Natural Sciences, 192-1 Hyoja-2-dong, Chuncheon 200-701, Korea.

2. College of Pharmacy, Sookmyung Women’s University, Seoul 140-742, Korea.

Abstract

A unique gene named pca1+, encoding a metacaspase, was cloned from the fission yeast Schizosaccharomyces pombe and was used to create a recombinant plasmid, pPMC. The metacaspase mRNA level was markedly elevated in the fission yeast cells harboring the plasmid pPMC. Overexpressed Pca1+appeared to stimulate the growth of the fission yeast cells instead of arresting their growth. Its expression was enhanced by stress-inducing agents such as H2O2, sodium nitroprusside, and CdCl2, and it conferred cytoprotection, especially against CdCl2. However, such protection was not reproducible in the budding yeast Saccharomyces cerevisiae harboring pPMC. Taken together, these results propose that Pca1+may be involved in the growth and stress response of the fission yeast.

Publisher

Canadian Science Publishing

Subject

Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/W07-067

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