Author:
Hanessian Stephen,Roy René
Abstract
The total stereocontrolled synthesis of the antibiotic spectinomycin is described, based on the regiospecific functionalization and manipulation of appropriate starting materials. The tertiary ketol rearrangement of the antibiotic and its derivatives was studied and the stereochemical identity of spectinoic acid was established by chemical correlation. Dihydrospectinomycin derivatives undergo unusual solvolysis reactions.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
59 articles.
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