Affiliation:
1. Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Canada
Abstract
The possible relationship between vitamin D toxicity and linoleate intake was investigated. Linoleate increased the survival time of essential fatty acid deficient rats given lethal doses of vitamin D but this effect was probably unspecific. Plasma calcium and kidney calcification, increased by vitamin D, was not influenced by linoleate intake while the fecal excretion of calcium was decreased by all fat supplements. Body fat composition was altered by a small daily intake of linoleate but not by large doses of vitamin D. Weight gains of rats given fat supplements and vitamin D were so variable that they were considered unsatisfactory criteria for judging the effect of linoleate intake on vitamin D toxicity.
Publisher
Canadian Science Publishing