THE ENHANCEMENT OF PENETRATION OF AN ORGANOPHOSPHORUS ANTICHOLINESTERASE THROUGH GUINEA PIG SKIN BY DIMETHYL SULFOXIDE

Abstract

The penetration of both intact and stripped guinea pig skin by soman was enchanced by dimethyl sulfoxide (DMSO), showing that DMSO does not act solely by increasing the penetration of stratum corneum. At high concentrations of DMSO the increase in penetration was masked by a decrease in the spreading of the mixtures on skin, but when this decrease was taken into consideration the penetration rate of soman increased with increasing DMSO concentrations up to at least 90%.