Author:
Coceani Flavio,Armstrong Craig,Kelsey Lois
Abstract
Endothelin was tested on isolated ductus arteriosus preparations from mature fetal Iambs. At low [Formula: see text] (18–24 Torr; 1 Torr = 133.3 Pa), the compound constricted the vessel dose-dependently over the range from about 10−10 to 10−7 M. The contraction was sustained and did not subside even after an extended period of washing. Endothelin was also effective on tissues ([Formula: see text], 217–231 Torr; indomethacin, 2.8 × 10−6 M) that had been completely relaxed with CO (CO/O2 ratio, 0.28). CO treatment interferes with a cytochrome P-450 mechanism, which is considered crucial for the contractile response of the vessel to oxygen. These findings are consistent with a role of endothelin in the closure of the ductus arteriosus at birth.Key words: ductus arteriosus closure, oxygen, cytochrome P-450.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
69 articles.
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