Drug-Induced Porphyrin Biosynthesis. X. Potentiation of Propanidid-Induced Elevation of δ-Aminolevulinic Acid Synthetase and Porphyrins in Chick Embryo Liver by the Carboxylesterase Inhibitor Bis-[p-nitrophenyl] Phosphate

Abstract

Propanidid, an ultra short-acting non-barbiturate anesthetic containing an ester group, induces δ-aminolevulinic acid (ALA)-synthetase and porphyrin accumulation in 17-day-old chick embryo liver. The potency and duration of action of propanidid in inducing ALA-synthetase activity and porphyrin accumulation was markedly increased when administered to chick embryos which had been pretreated with bis-[p-nitrophenyl] phosphate, an inhibitor of liver carboxylesterase.