Effect of clofibrate treatment on chronic hyperlipidemia induced by an ACTH-producing tumor

Abstract

Plasma triglyceride and cholesterol levels were significantly increased in rats bearing an MtT-F4 tumor for 31–41 days. Addition of clofibrate at a dose of 30 mg kg−1 day−1 to the diet of rats bearing the tumor resulted in the complete elimination of the tumor effect on the plasma triglycerides, and to a great extent prevented the rise in the plasma cholesterol.