Effets des purines et des pyrimidines sur la croissance de Corynebacterium sepedonicum (Spiek. & Kott.) Skapt. & Burkh.

Abstract

The effects of purines and pyrimidines on the growth of Corynebacterium sepedonicum were studied in a synthetic medium containing amino acids, vitamins, mineral salts, and glucose. Among four purines tested, only adenine inhibited the growth of the organism. Hypoxanthine and guanine reversed the inhibition caused by adenine. None of four pyrimidines tested affected the growth. In the presence of pyrimidines, only hypoxanthine reversed the inhibition caused by adenine. It appears that purines and pyrimidines do not stimulate the growth of C. sepedonicum and that the synthesis of nucleic acids from these bases is not a limiting factor in the growth of the organism.