Selective Inhibition of Hemoglobin Formation in Chick Embryo Blood Islands by Chloramphenicol

Abstract

Chloramphenicol markedly inhibited the formation of hemoglobin by chick blastodiscs explanted before the 8-somite stage of development onto minimal or egg homogenate medium. Sensitivity to inhibition of hemoglobin formation was reduced at the 8-somite stage. Chloramphenicol had no effect upon the incorporation of leucine into total protein, and only slightly inhibited the cycloheximide-resistant incorporation of leucine.