Action de l'amphotéricine B sur la composition en stérols de Kluyveromyces bulgaricus et Kluyveromyces lactis

Abstract

The degree of sensitivity of the yeasts Kluyveromyces bulgaricus and K. lactis to amphotericin B is linked to a difference in the sterol composition of their membranes. No direct proportionality was found between sensitivity and the quantity of sterols present. At sublethal doses, amphotericin B perturbed sterol synthesis, resulting in ergosterol precursor accumulation. An ergosterol pathway is proposed for Kluyveromyces. [Translated by the journal]