EFFECT OF AMPHENONE B ON DEVELOPMENT OF RENAL HYPERTENSION IN RATS

Abstract

The effect of Amphenone B on development of renal hypertension was studied in rats whose kidneys were encapsulated with latex envelopes. The compound was administered in the diet for 13 weeks at dose levels of 0.1 and 0.3% by weight. Both dose levels of Amphenone B were equally effective in preventing rise of systolic blood pressure to the level of untreated, renal-encapsulated controls although both doses of the drug allowed modest rises of pressure to occur. Growth was inhibited by the drug. Amphenone B depressed thyroid activity as assessed by increased release rate of radioactive iodide from the thyroid gland; decreased resting metabolic rate; decreased growth; decreased food intake; and increased thyroid size. The protection against development of hypertension afforded by this compound may be related, at least in part, to its antithyroid activity.