EFFECT OF AGING AQUEOUS NITROGEN MUSTARD ON WHITE BLOOD CELL COUNT, BODY WEIGHT, AND WALKER 256 TUMOR IN THE RAT

Abstract

Aging an aqueous solution of nitrogen mustard up to 3 days did not alter significantly its ability to decrease the white blood cell count, body weight, or the growth of the established Walker 256 tumor in the rat. There was a direct relationship between the decrease in white blood cell count and depression of tumor growth but not between the depression of body weight and tumor growth. The acidity of aqueous nitrogen mustard (0.5 mg/ml) increased exponentially with time up to 100 days but was not related to the ability to decrease the white blood cell count, body weight, or tumor growth.