Amine and thiazole substituted γ-butyrolactones from naturally occurring limonene

Author:

Kaur Pushpinder1,Das Pralay1,Chaudhary Abha1,Singh Bikram1

Affiliation:

1. Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur (H.P.) 176061, India.

Abstract

Substituted γ-butyrolactones are important structural motifs in several natural products and pharmaceuticals. In this paper, we report the synthesis of novel γ-butyrolactone amine and thiazole derivatives from naturally occurring limonene. Regioselective bromination followed by nucleophilic substitution with different amines and thiourea gave desired products in moderate yield.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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