One-pot synthesis of benzopyrano[2,3-d]pyrimidine derivatives catalyzed by LDHs@Propyl-ANDSA

Abstract

A general, effective, and operationally simple approach to highly substituted benzopyrano[2,3-d]pyrimidine through the annulation of salicylaldehydes, malononitrile, and secondary amines is explained. The reaction is promoted by the Brønsted–Lowry acid, furnishing a variety of benzopyrano[2,3-d]pyrimidine derivatives in synthetically useful yields.