Structure of the principal antineoplastic glycosides of Phyllanthusacuminatus Vahl

Abstract

A series of degradative and X-ray crystallographic studies has led to unequivocal evidence for the structure (3a) assigned to the unique disaccharide phyllanthose. In turn, the X-ray crystal structure of phyllanthose confirms structures previously assigned to the potentially important antineoplastic plant glycosides phyllanthostatins 1 and 2 (1a, c) and phyllanthoside (1b). The chemical degradation and crystallographic analyses allowed assignment of structure 2a to phyllanthostatin 3.