Author:
Rakhit S.,Deghenghi R.,Engel Ch. R.
Abstract
The synthesis fo 17α-bromo-6α-methylprogesterone, from pregnenolone acetate, is reported. The product is a potent luteoid with marked oral activity. In the course of this investigation, a useful variation of the synthesis of 6α-methylprogesterone, from pregnenolone, was devised. The rearrangement of a 5β,6β-epoxide to a 6-ketone, upon chromatography on aluminum oxide "Woelm", was observed.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
10 articles.
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