Phosphofructokinase and glycolysis in the livers of rats fed a thrombogenic diet

Abstract

Liver supernatant phosphofructokinase activity is increased in rats fed a thrombogenic diet at about the same time as the incidence of endotoxin-induced thrombosis is known to increase. In the livers of these rats, the Pasteur effect, as determined by the production of lactic acid in a reconstituted system containing a high-speed supernatant with and without the mitochondrial fraction, is significantly decreased.