Mechanism of Inhibition of Smooth Muscle Tension in Guinea-Pig Taenia Coli by Ouabain

Author:

Bose D.

Abstract

Ouabain produced an increase in tension in the guinea-pig taenia coli which was abolished in the presence of high extracellular potassium. On the other hand the delayed inhibitory response of ouabain could only be abolished by the removal of extracellular sodium. The mechanism of inhibition of contraction by ouabain appears to be due to elevation of intracellular sodium concentration.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Altered smooth muscle contraction and sodium pump activity in the inflamed rat intestine;American Journal of Physiology-Gastrointestinal and Liver Physiology;1989-10-01

2. Contractile responses of the guinea-pig vas deferens to the combination of vanadium ions with ouabain;General Pharmacology: The Vascular System;1989-01

3. The influence of ouabain on twitch contractions in the presence of veratridine;General Pharmacology: The Vascular System;1989-01

4. Endothelium-dependent hyperpolarization of canine coronary smooth muscle;British Journal of Pharmacology;1988-03

5. The Electrogenic NA+,K+-Pump in Smooth Muscle: Physiologic and Pharmacologic Significance;Annual Review of Pharmacology and Toxicology;1980-04

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