Affiliation:
1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences prosp. Oktyabrya 141, 450075 Ufa, Russian Federation.
Abstract
Novel side chain ω-fluorinated ecdysteroid analogues were obtained starting from ω-functionalized ecdysteroids. Thus, the reaction of diacetonides of 25RS-hydroxy- and 24-hydroxy 27-nor- and 25,26,27-tris-nor-20-hydroxyecdysone derivatives with diethylaminosulfur trifluoride (DAST) involves replacement of the terminal hydroxyl group and dehydration at the 14-position to give 25RS-fluoro- and 24-fluoro-14-anhydro analogues of ecdysteroids.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Reference19 articles.
1. Dinan, L. In Studies in International Products Chemistry; Atta-ur-Raman, Ed.; Elsevier: Amsterdam, 2003; pp. 3–71.
2. Cymborowski, B. In Ecdysone, from Chemistry to Mode of Action; Koolman, J., Ed.; Georg Thieme: Stuttgart, 1989; pp. 144–149.
3. Synthesis of 25-fluoroponasterone A, a fluorinated analogue of 20-hdyroxyecdysone.
4. Practical uses for ecdysteroids in mammals including humans: and update
5. Phytoecdysteroids and Anabolic-Androgenic Steroids - Structure and Effects on Humans
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献