Affiliation:
1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences prosp. Oktyabrya 141, 450075 Ufa, Russian Federation.
Abstract
Novel side chain ω-fluorinated ecdysteroid analogues were obtained starting from ω-functionalized ecdysteroids. Thus, the reaction of diacetonides of 25RS-hydroxy- and 24-hydroxy 27-nor- and 25,26,27-tris-nor-20-hydroxyecdysone derivatives with diethylaminosulfur trifluoride (DAST) involves replacement of the terminal hydroxyl group and dehydration at the 14-position to give 25RS-fluoro- and 24-fluoro-14-anhydro analogues of ecdysteroids.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
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