Common bed bugs can biosynthesize pheromone components from amino acid precursors in human blood

Author:

Gries Regine1,Zhai Huimin2,Lewis Andrew R.2,Britton Robert2,Gries Gerhard1

Affiliation:

1. Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.

2. Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.

Abstract

We have recently shown that the aggregation pheromone of the common bed bug, Cimex lectularius, comprises a six-component blend of dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS), (E)-2-hexenal, (E)-2-octenal, 2-hexanone, and histamine. Here, we tested the hypothesis that bed bugs biosynthesize some pheromone components from amino acid precursors in human blood, namely DMDS and DMTS from L-methionine and histamine from histidine. We tested this hypothesis by (i) allowing bed bugs to feed on and metabolize sheep blood enriched with 13C-labelled histidine or 2H-labelled methionine, (ii) extracting bed bug feces (a source of the aggregation pheromone), and (iii) analyzing feces extracts by GC-MS, HPLC-MS and NMR spectroscopy. The analyses revealed that bed bugs converted 2H-methionine to 2H-DMDS and 2H-DMTS, and 13C-histidine to 13C-histamine. There is not enough histidine in human blood to account for the amount of histamine that bed bugs produce and excrete with their feces, and only a small proportion of the available 13C-histidine was converted to 13C-histamine in our study. Therefore, it is likely that bed bugs biosynthesize histamine, and possibly also DMDS and DMTS, primarily de novo.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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