Affiliation:
1. Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Montréal, QC H3C 3J7, Canada
Abstract
In this review, I describe our scientific journey to unearth the impact of RNA metabolism in cancer using the eukaryotic translation initiation factor eIF4E as an exemplar. This model allowed us to discover new structural, biochemical, and molecular features of RNA processing, and to reveal their substantial impact on cell physiology. This led us to develop proof-of-principle strategies to target these pathways in cancer patients leading to clinical benefit. I discuss the important role that the unexpected plays in research and the necessity of embracing the data even when it clashes with dogma. I also touch on the importance of equity, diversity, and inclusion to the success of the scientific enterprise.
Funder
National Institutes of Health
Canadian Institutes of Health Research
Leukemia and Lymphoma Society
Leukemia and Lymphoma Society of Canada
Canada Research Chairs
Publisher
Canadian Science Publishing
Subject
Cell Biology,Molecular Biology,Biochemistry