The search for genetic dark matter and lessons learned from the journey

Author:

Borden Katherine L.B.1ORCID

Affiliation:

1. Institute for Research in Immunology and Cancer, Department of Pathology and Cell Biology, Université de Montréal, Montréal, QC H3C 3J7, Canada

Abstract

In this review, I describe our scientific journey to unearth the impact of RNA metabolism in cancer using the eukaryotic translation initiation factor eIF4E as an exemplar. This model allowed us to discover new structural, biochemical, and molecular features of RNA processing, and to reveal their substantial impact on cell physiology. This led us to develop proof-of-principle strategies to target these pathways in cancer patients leading to clinical benefit. I discuss the important role that the unexpected plays in research and the necessity of embracing the data even when it clashes with dogma. I also touch on the importance of equity, diversity, and inclusion to the success of the scientific enterprise.

Funder

National Institutes of Health

Canadian Institutes of Health Research

Leukemia and Lymphoma Society

Leukemia and Lymphoma Society of Canada

Canada Research Chairs

Publisher

Canadian Science Publishing

Subject

Cell Biology,Molecular Biology,Biochemistry

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