The reactions of isothiazolium salts with selected nucleophilic reagents. The preparation of thieno[2,3-c]isothiazolium salts

Abstract

Isothiazolium salts react with a number of carbanions by attack on sulfur. Thiophene derivatives, formed by ring opening and recyclization, are often products but with cyclopentadiene, pseudoazulene products are obtained. 3-Amino-2-acylthiophenes, prepared by suitable nucleophilic attack, are synthetic precursors of thieno[2,3-c]isothiazolium salts