Species differences of amobarbital metabolism: dihydroxyamobarbital formation

Abstract

Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3′-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3′,4′-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.