Genetic diversity in the stress regulatory gene LUMAN/CREB3 of Yorkshire and Meishan pigs

Author:

Larson Shayla1,Zhou Rong2,Li Kui2,Zhang Yani3,Jafarikia Mohsen45,Bergeron Renée4,Lu Ray1

Affiliation:

1. Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.

2. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100091, People’s Republic of China.

3. College of Animal Science and Technology, Yangzhou University, Jiangsu 225000, People’s Republic of China.

4. Department of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

5. Canadian Centre for Swine Improvement Inc., Central Experimental Farm, Building #75, 960 Carling Avenue, Ottawa, ON K1A 0C6, Canada.

Abstract

A candidate-gene high-density single-nucleotide polymorphism (SNP) scanning approach was used to investigate the swine LUMAN/CREB3 locus for polymorphisms in 232 Ontario Yorkshire and 29 Chinese Meishan pigs. Inter- and intra-breed differences in genetic diversity were characterized. In the Yorkshire breed, eight variations (three coding and five non-coding) were identified. Two linkage disequilibrium (LD) blocks (550 bp and ∼4 kb in length) featuring two and three haplotypes, respectively, were reconstructed. In the Meishan breed, six variations (two coding and four non-coding) and one LD block (∼3 kb in length) with three haplotypes were detected. This investigation may provide insight into variable stress responsiveness among pigs.

Publisher

Canadian Science Publishing

Subject

Animal Science and Zoology,Food Animals

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