RELATIVE POSITIONS OF CHROMOSOME 1 LOCI Fy, PGM1, Sc, UMPK, Rh, PGD AND ENO1 IN MAN

Abstract

Ongoing linkage studies of red cell antigens and enzymes in many families along with concentration on a large Mennonite kindred segregating for Sc have resulted in lods, recombinant: nonrecombinant counts and multi-point information which support an order with approximate recombination fractions as measured in the male as follows: Fy -.25 - PGM1 -.20 - Sc - <.05 - UMPK -.15 - Rh -.20 - PGD, with ENO1 close to PGD. The insertion of Sc and UMPK between PGM1 and Rh allows the recognition of double crossing-over between the latter pair; indications are that this is not a rare event in the female. In the male no evidence of double crossing-over was found in the similar distances PGM1 - Rh and Sc - PGD in 13 and 19 opportunities respectively.