Phosphonodipeptides: synthesis and separation of diastereoisomers

Author:

Kafarski Paweł,Lejczak Barbara,Mastalerz Przemsław,Szewczyk Jerzy,Wasielewski Czesław

Abstract

Diastereoisomeric mixtures of phosphonodipeptides, prepared from racemic dialkyl 1-aminoalkanephosphonates, were separated by ion-exchange column chromatography. Phosphonodipeptides were found to be much more readily available from dialkyl 1-aminoalkanephosphonates than from the corresponding free acids and the mixed carboxylic – carbonic anhydride method was found to be the most effective one.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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