Abstract
An interpretation of the mechanism of action of "Dibenamine" is offered and the conclusion is reached that the excitatory receptors most probably include a carboxylate or phosphate anion as an active center. On the basis of a combination of isosteric and chemical reactivity principles, a precise correlation between structure and pharmacological activity of adrenergic blocking β-haloalkylamines is described. Structural similarities between sympathomimetic amines and adrenergic blockers are uncovered and applied to the interpretation of the activity of several hundred β-haloalkylamines. The crucial point of the discussion revolves about the concept of a phenethylamine pattern illustrated in Figs. 1 and 2 and it is demonstrated that this pattern applies generally to active adrenergic blocking β-haloalkylamines and that it allows predictions of activity.
Publisher
Canadian Science Publishing
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献