Author:
Kalant H.,Mons Wilhelmina,Guttman Marta
Abstract
Total sialic acid content of rat livers and tumors was determined by acid hydrolysis of tissue samples, isolation on Dowex-2 columns, and reaction with thiobarbituric acid. Normal rat liver was found to contain 465 μg of neuraminic acid per g of fresh tissue. In rats bearing hepatomata induced by the feeding of p-dimethylaminoazobenzene, the tumors contained an average of 1162 μg/g, while the surrounding liver contained 587 μg/g. Treatment of tissue sections with purified neuraminidase liberated only 27–28% of the sialic acid from liver tissue, but 49% of that in the hepatomata. Paper chromatographic analysis indicated a difference between normal liver and hepatomata with respect to the types of sialic acid present.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
6 articles.
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