Novel chiral proline-based organocatalysts with amide and thiourea–amine units for highly efficient asymmetric aldol reaction in saturated brine without additives

Abstract

A series of novel proline-based organocatalysts with amide and thiourea-amine units (7a–7f) were developed and evaluated in the asymmetric aldol reaction of 4-nitrobenzaldehyde with cyclohexanone. The organocatalyst (7c or 7d, 5 mol%) exhibited efficient catalytic activity to afford aldol products in high diastereoselectivity (up to >99:1), enantioselectivity (up to >99%), and yield (up to >96%) at 0 °C in saturated brine without adding an acid. Aldol products of benzaldehyde derivatives almost universally provide high diastereoselectivity and enantioselectivity.