Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen

Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen–progestin

Published:2018-11 Issue:11 Volume:96 Page:1092-1103
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Omolekulo Tolulope Eniola¹,Areola Emmanuel Damilare¹,Badmus Olufunto Olayinka¹²,Michael Olugbenga Samuel¹³,Kim Inkyeom⁴,Olatunji Lawrence Aderemi¹

Affiliation:

1. HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.

2. Department of Public Health, Kwara State University, Malete, Nigeria.

3. Cardiometabolic Research Unit, Department of Physiology, College of Health Sciences, Bowen University, Iwo, Nigeria.

4. Cardiovascular Research Institute and Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/cjpp-2018-0231

Reference71 articles.

1. One-Hour Plasma Glucose Concentration and the Metabolic Syndrome Identify Subjects at High Risk for Future Type 2 Diabetes

2. Physiological Control of Liver Glycogen Metabolism: Lessons from Novel Glycogen Phosphorylase Inhibitors

3. Hypoglycemic, antilipidemic and antioxidant effects of valproic acid in alloxan-induced diabetic rats

4. Anti-inflammatory Effects of Valproic Acid in a Rat Model of Renal Ischemia/Reperfusion Injury: Alteration in Cytokine Profile

5. Dipeptidyl Peptidase-4 Inhibition Ameliorates Western Diet–Induced Hepatic Steatosis and Insulin Resistance Through Hepatic Lipid Remodeling and Modulation of Hepatic Mitochondrial Function

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1. Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen–progestin contraceptive-induced hyperinsulinemic female rats;Canadian Journal of Physiology and Pharmacology;2021-12

2. Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam;Journal of the Renin-Angiotensin-Aldosterone System;2021-05-17

3. Allopurinol and valproic acid improve cardiac triglyceride and Na+-K+-ATPase activity independent of circulating aldosterone in female rats with glucose intolerance;Archives of Physiology and Biochemistry;2020-05-23