Oxidative stress and cardiovascular health: therapeutic potential of polyphenols-Reference-Cited by-同舟云学术

Oxidative stress and cardiovascular health: therapeutic potential of polyphenols

Published:2013-03 Issue:3 Volume:91 Page:198-212
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Khurana Sandhya¹,Piche Matthew¹,Hollingsworth Amanda²,Venkataraman Krishnan¹,Tai T.C.³

Affiliation:

1. Medical Sciences Division, Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.

2. Medical Sciences Division, Northern Ontario School of Medicine, and Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.

3. Medical Sciences Division, Northern Ontario School of Medicine, and Department of Chemistry and Biochemistry, Department of Biology, and the Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.

Abstract

Reactive oxygen species (ROS) are important in normal cellular function and physiology. However, oxidative stress resulting from an accumulation of ROS has a detrimental impact on cellular function, and ROS has been implicated in the pathogenesis of a number of diseases, including cardiovascular diseases. This review provides a summary of the impact of ROS on cardiovascular health and diseases, highlighting the therapeutic use of antioxidants. In addition, this review summarizes the health benefits of polyphenols, and the recent progress on understanding the cellular and physiological actions by which polyphenols may impart their beneficial properties on cardiovascular health.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/cjpp-2012-0252

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