Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats

Author:

Bashandy Samir A.E.1,Alaamer Abdulaziz2,Moussa Sherif A. Abdelmottaleb23,Omara Enayat A.4

Affiliation:

1. Department of Pharmacology, Medical Division, National Research Centre, 33 EL Bohouth St. (former EL Tahir St.), Dokki, Giza, Egypt. P.O.12622.

2. Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

3. Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, 33 EL Bohouth St. (former EL Tahir St.), Dokki, Giza, Egypt P.O.12622.

4. Department of Pathology, Medical Division, National Research Centre, 33 EL Bohouth St. (former EL Tahir St.), Dokki, Giza, Egypt. P.O.12622.

Abstract

The present research studied the influence of zinc oxide nanoparticles (ZnO-NPs; 5, 7.5, and 10 mg/kg, i.p.) on the liver and kidney injuries motivated by thioacetamide (TAA; 100 mg/kg, i.p.). Each treatment was carried out 3 times per week for 8 weeks. ZnO-NPs relieved the decrease of hepatic or renal reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) induced by TAA. Moreover, ZnO-NPs lowered tissue malondialdehyde (MDA, an indicator for lipid peroxidation). TAA treatment led to a significant increase in plasma inflammatory markers (TNF-α, IL-6), liver enzymes (gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and kidney function parameters (creatinine, urea, uric acid). However, these parameters were reduced after treatment with ZnO-NPs. In addition, the hepatic fibrosis markers, hydroxyproline level, and α-smooth muscle actin immunopositive stain were lowered by ZnO-NPs. The protective effect of ZnO-NPs in respect to biochemical changes was also confirmed by histopathological and immunohistochemistry studies in the liver and kidney sections. Our results suggested that ZnO-NPs may attenuate TAA toxicity via suppression of oxidative stress.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

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