Inhibition by antidepressants of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes

Abstract

Effects of antidepressive drugs on glibenclamide-sensitive K+ currents were investigated using follicle-enclosed Xenopus oocytes. Antidepressive drugs, imipramine, desipramine, and amitriptyline, inhibited the K+ currents with IC50 (μM) values of 35.4, 39.7, and 87.7, respectively. The K+ current blocking actions of antidepressants appear to be associated with their local anesthetic related structures.Key words: K+ currents, glibenclamide, antidepressive drug, Xenopus oocyte.