Antibody to an artificial disaccharide antigen cross-reactive with Neisseria gonorrhoeae lipopolysaccharide

Author:

Bundle David R.

Abstract

An artificial antigen was prepared from 4-O-β-D-galactopyranosyl-D-glucose (lactose) and 8-ethoxycarbonyloctanol. Covalent attachment to bovine serum albumin provided an antigen that elicited antilactose antibody in rabbits and goat. These antibodies were active against Neisseria gonorrhoeae lipopolysaccharide in passive hemagglutination tests. The same antibody agglutinated cells of Streptococcus faecalis, strain N, and precipitated the lactose-containing cell wall diheteroglycan of this organism. Fractionation of rabbit and goat antibody raised against the synthetic antigen of S. faecalis vaccine provided two antibody fractions only one of which, eluted from the immunoadsorbent by galactose, was active against N. gonorrhoeae lipopolysaccharide.

Publisher

Canadian Science Publishing

Subject

General Medicine

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Model α-mannoside conjugates: immunogenicity and induction of candidacidal activity;FEMS Immunology & Medical Microbiology;2010-04

2. EXEMPLIFICATION OF SEROLOGICAL CROSS-REACTIVITY OF NEISSERIA LIPOPOLYSACCHARIDES;Acta Pathologica Microbiologica Scandinavica Series B: Microbiology;2009-08-15

3. Large-scale chemical and chemo-enzymatic synthesis of a spacer-containing Pk-trisaccharide;Carbohydrate Research;2004-04

4. C;Dictionary of Carbohydrates;1998

5. Synthesis of multivalent β-lactosyl clusters as potential tumor metastasis inhibitors;Carbohydrate Research;1993-07

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