Abstract
The changes in the activity of five representative lysosomal enzymes of rat liver and kidney, namely acid phosphatase, β-glucuronidase, β-galactosidase, arylsulfatase, and cathepsin D, during starvation and refeeding have been studied. When rats were fasted for periods of up to 120 h, both free and total activities of hepatic lysosomal enzymes progressively increased reaching levels two to seven times higher than those of fed controls. On resuming feeding at the end of a starvation period, enzyme activities rapidly returned to normal. There was a close relationship between increased lysosomal enzymes during starvation and loss in liver and body weights of the animal. These findings, taken together, suggest a specific role for lysosomal enzymes in adaptive processes requiring turnover of body tissues for maintenance and survival of the animal without doing itself irreparable damage during starvation.
Publisher
Canadian Science Publishing
Cited by
33 articles.
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