ANTICOAGULANT EFFECT OF INCUBATED FIBRINOGEN

Author:

Triantaphyllopoulos D. C.

Abstract

Sterile fibrinogen rendered non-clottable by incubation was mixed with fresh plasma and the thrombin time determined. An appreciable prolongation was observed. The incubated fibrinogen was then fractionally precipitated with ammonium sulphate. The material precipitated between 25 and 50% ammonium sulphate saturation, when added to freshly drawn but still unclotted blood, or native plasma, prevented its coagulation. This action could be reversed by an approximately fivefold dilution with distilled water and addition of calcium chloride and thrombin, thus excluding fibrinolysis as the cause of the anticoagulant effect. Determinations of the respective coagulation factors showed that no decrease occurred in prothrombin, factor VII, plasma thromboplastin component, and fibrinogen. On the other hand a statistically significant decrease in factor V was observed when calcium was present.

Publisher

Canadian Science Publishing

Subject

General Medicine

Cited by 49 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. 3. IDENTIFICATION AND PURIFICATION OF FIBRINOGEN DEGRADATION PRODUCTS PRODUCED BY PLASMIN: CONSIDERATIONS ON THE STRUCTURE OF FIBRINOGEN;Scandinavian Journal of Haematology;2009-04-24

2. Demonstration of Fibrinolytic Split Products in Human Serum by an Immunological Method in Spontaneous and Induced Fibrinolytic States;Scandinavian Journal of Haematology;2009-04-24

3. FIBRINOLYTIC BLEEDING AND ITS MANAGEMENT*;Annals of the New York Academy of Sciences;2006-12-16

4. Blood Coagulation and Fibrinolysis;Comprehensive Physiology;1985-12

5. Influence of fibrinogen on fibrin polymerization. Ultracentrifugation studies;Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology;1985-07

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