EFFECTS OF E-A.C.A. IN SPONTANEOUS HEMORRHAGE DUE TO STRESS WITH ANTICOAGULANTS IN RATS

Abstract

Epsilon aminocaproic acid was used in an attempt to prevent the hemorrhagic manifestation that occurs when a stressor agent is combined with anticoagulant in rats. Groups of rats were subjected to restraint or lysergic acid diethylamide (L.S.D.) and then given an anticoagulant, phenylindanedione, for 10 days. Other groups were subjected to twice-daily injections of physiological saline, during the 10 days of experiment, simultaneously with the anticoagulant. Close observations were made to evaluate any hemorrhagic manifestation. Postmortem examination was performed on the rats that died during the experiment, and on the survivors which were sacrificed upon conclusion of the 10 day period. Restraint, L.S.D., and twice-daily injections of physiological saline subcutaneously all caused spontaneous hemorrhage in anticoagulant-treated animals. The administration of E-A.C.A. by subcutaneous injection or in the drinking water during the 10 day duration of the experiment did not prevent the high incidence of hemorrhage in the groups when the stressor agent was combined with anticoagulant.