Abstract
The relative antibacterial activities of penicillins and cephalosporins are discussed in terms of their differing abilities to complex to and react with penicillin-binding proteins. The insights gained from such an analysis are being used to attempt the design of new kinds of structures targeted to the penicillin receptor. Details of such design, and examples of several new classes of compounds suggested by this work, are described. Some of these compounds exhibit interesting antibacterial activity.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
25 articles.
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